Estrogen receptor beta gene polymorphisms are linked with higher bone mineral density in premenopausal but not in postmenopausal women.
This finding in a study among 325 healthy southern Chinese women raises the possibility the estrogen receptor beta (ERbeta) gene plays a modulatory role in bone metabolism in young adults, suggest Dr. H. H. Lau and colleagues from the University of Hong Kong, Queen Mary Hospital, Hong Kong.
Bone mineral density (BMD), the main determining risk factor for osteoporotic fractures, has a strong genetic component; estrogen and its receptors are key in both skeletal maturity and bone loss. Thus, these researchers investigated the link between BMD and dinucleotide (cytosine-adenine; CA) repeat polymorphisms in the flanking region of the ERbeta gene in these women, 120 of them premenopausal and 205 postmenopausal.
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