“Because of [the] potential for a severe reaction, asthmatics are usually consistently warned to avoid aspirin and NSAIDs [nonsteroid anti-inflammatory drugs] by physicians, package inserts, the Internet, nurses, pharmacists, and the press,” lead author Katharine M. Woessner, from the Scripps Research Institute in La Jolla, California, says in a news release. “As a result, many patients with asthma are not receiving adequate anti-inflammatory therapy for a variety of conditions.”
In this study, 60 asthmatic patients with a documented history of aspirin-provoked attacks underwent a placebo-controlled challenge with celecoxib, 100 mg and 200 mg, while being monitored for a 48-hour period. On the following day, single-blinded aspirin challenges confirmed aspirin sensitivity in all patients, with a mean provoking dose of 69 mg.
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