As people age, they maintain the circadian rhythms which govern the patterns of their blood lipids.
A dietary schedule, therefore, greatly helps to synchronise the daily lipid profile, say researchers at the Universities of Pavia and Insubria, Varese, Italy.
The researchers noted that there had been reports of changed rhythms in old people because of structural and neurochemical changes in the central nervous system.
Since alterations of lipid and lipoprotein metabolism were directly involved in several age-related disorders, the researchers investigated the circadian temporal organisation of total cholesterol, triacylglycerol, apolipoprotein A1 and apolipoprotein B in 30 elderly hospital patients, with 24 healthy young people as controls.
The patients were synchronised for daily activities, sleeping and waking habits and the time and quality of their meals. After an overnight fast, samples were taken at 8 a.m., then every four hours until 8 p.m. and then every two hours until 4 a.m.
Data on rhythms were analysed by single and population mean Cosinor analysis and by ANalysis Of VAriance between groups (ANOVA). Rhythm parameters in patients and controls were compared by the Mesor test. Hotelling’s test was used to gauge amplitude-acrophase.
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