– Scientists at The Rockefeller University in New York report that they have identified a specific hepatic enzyme that is downregulated by the leptin gene, which leads to leaner animals that have more energy expenditure.
Suppression of RNA synthesis of hepatic stearoyl-CoA desaturase-1 (SCD-1) resulted in the changes, according to the report in the July 12th issue of Science by Dr. Jeffrey M. Friedman and colleagues at Rockefeller and at the University of Wisconsin, Madison.
The team found that found that leptin-deficient (ob/ob) mice who were also deficient in SCD-1 had a 40% reduction in body mass and a 75% increase in energy expenditure compared with ob/ob controls who did not have a decreased expression of the SCD-1 gene. The SCD-1 deficient mice had very low triglyceride and VLDL cholesterol production and livers that were histologically normal.
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