NEW YORK (Reuters Health) Jul 02 –
The cyclooxygenase-2 inhibitor valdecoxib is as effective as naproxen for treating osteoarthritis of the knee, according to a report in the June issue of The Journal of Family Practice.
Upper gastrointestinal safety is significantly better with valdecoxib. In a multicenter, randomized, double-blind, placebo-controlled study, researchers compared the efficacy and upper gastrointestinal tract safety of 5-, 10- and 20-mg valdecoxib once daily with placebo and with 500-mg naproxen twice daily in patients with osteoarthritis of the knee.
Dr. David P. Recker, of Pharmacia Corporation, in Skokie, Illinois, and colleagues assessed the Patient’s and Physician’s Global Assessment of Arthritis (PaGAA, PhGAA), Patient’s Assessment of Arthritis Pain-Visual Analog Scale (PAAP-VAS), and Western Ontario and McMaster’s Universities (WOMAC) Osteoarthritis indices at baseline, and at 2, 6, and 12 weeks. Pre- and posttreatment endoscopies were used to assess upper gastrointestinal ulceration.
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