Obesity in adolescent and young adult men is associated with the extent and severity of coronary atherosclerosis, based on autopsy findings reported in the June 11th issue of Circulation.
Dr. Henry C. McGill, Jr., of the University of Texas Health Science Center at San Antonio, and colleagues with the Pathobiological Determinants of Atherosclerosis in Youth study, examined arteries, blood, and other tissue from approximately 3000 males and females 15 to 34 years of age who died of external causes.
“We measured gross atherosclerotic lesions in the right coronary artery (RCA), American Heart Association (AHA) lesion grade in the left anterior descending coronary artery (LAD), serum lipid concentrations, serum thiocyanate (for smoking), intimal thickness of renal arteries (for hypertension), glycohemoglobin (for hyperglycemia), and adiposity by body mass index (BMI) and thickness of the panniculus adiposus,” the team explains.
They observed an association between BMI in young men and fatty streaks (p=0.0001) and raised lesions (p=0.0001) in the RCA as well as AHA grade and stenosis in the LAD. “The effect of obesity (BMI>30 kg/m ) on RCA raised lesions was greater in young men with a thick panniculus adiposus,” the investigators note.
e-Med Tools
קצר קולע וממוקד
e-Med סמינרים
אי-מד תחקירים
Medscape Tools
Journal Club
מרכזי מידע ושירות
Facebook
מידע למפרסם
מאגר תרופות
מאגר אנשי המקצוע
אינדקס שימושי
חדשות משה"ב
eMed HealthClub
מחקרים קליניים
השאירו תגובה
רוצה להצטרף לדיון?תרגישו חופשי לתרום!