Small, standardised right hippocampal volumes could be significantly associated with remission in depression in geriatric patients.
Taiwanese and American researchers found when they compared the lowest quartile of standardised hippocampal volumes in depressed geriatric patients to those above the first quartile, patients with small right and total hippocampal volumes were less likely to achieve remission.
But, the investigators from the Chung Shan Medical and Dental College Hospital in Taiwan and Duke University Medical Centre in Durham, North Carolina say further studies with larger samples of patients are needed to determine if left-right hippocampal volume differences do exist in depression. They suggest basic neuroscience studies are needed to elucidate the role of the hippocampus in geriatric depression.
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