The influence of alcohol on lipid metabolism depends on the context in which it occurs. Biological, environmental and genetic factors interact to determine cardiovascular disease risk.
Researchers in Montreal and Sherbrooke, Quebec, Canada, and at the University of Michigan, Ann Arbor, Michigan, United States, noted that while hyperlipidaemia, smoking and obesity were well-known risk factors for cardiovascular disease, moderate drinking seemed to lower atherosclerosis risk.
The influence of alcohol on the links between these factors in a particular context had not been thoroughly investigated, leading the researchers to study the association between plasma measures of lipid metabolism and alcohol intake, to see if it was dependent on context defined by sex, age, body mass index, smoking and apolipoprotein E genotype.
Data came from a sample of 869 women and 824 men in the Quebec Heart Health Survey. There was no evidence that variation among apolipoprotein E genotypes influenced the association between alcohol and low density lipoprotein (LDL) cholesterol or high density
lipoprotein (HDL) cholesterol after adjusting for age and body mass index.
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