05/27/2002 By Veronica Rose
Sedative-hypnotics may lead to changes in body temperature but the promotion of sleep appears to vary between agents.
Previous research suggested that there was an association between the sleep-promoting effects of the sedative-hypnotics such as melatonin and temazepam and a fall in core body temperature. In this study, scientists at the Centre for Sleep Research, University of South Australia in Woodville investigated whether alterations in body temperature were a general feature of these drugs.
In addition, melatonin and zopiclone were compared to determine sleep inducing, core and peripheral temperature effects. In a double-blind, crossover design, 12 patients (seven males, five females, average age 20.3 years) were given melatonin (5mg), zopiclone (Imovane (TM); 7.5 mg) or a placebo 14.00 hours.
The had been supine from 08.00 to 21.30 hours, in single, light and temperature controlled rooms .
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