Journal of Clinical Pathology
04/29/2002
By Harvey McConnell
Remote partial gastrectomy for management of peptic ulcer seems to increase the long-term risk of a patients developing pancreatic cancer.
This has been found among a cohort of 2,633 patients who underwent surgery for the removal of a peptic or duodenal ulcer between 1931 and 1960. A preliminary analysis in 1988 suggested that these patients had double the risk of developing pancreatic cancer.
The aim of Dr Johan Offerhaus and colleagues at the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, was to determine if the risk increased with length of survival after surgery. They also sought to discover if there were any genetic differences between patients developing the disease after surgery and those who developed it spontaneously.
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