PHILADELPHIA, PA — April 30, 2002 — Results from a study published recently in Diabetes/Metabolism: Research and Reviews showed that adding the insulin sensitizing agent Avandia® (rosiglitazone maleate) to metformin significantly helped improve blood sugar levels in Mexican patients whose type 2 diabetes was inadequately controlled by metformin alone. Type 2 diabetes is the third leading cause of death in Mexico and is also a serious and growing problem among Mexican immigrants to the United States. Indeed, in the United States, diabetes currently affects more than one million Mexican- Americans, resulting in an increased incidence of diabetes-related complications compared to non-Hispanic Caucasians. This is largely attributed to a higher incidence of insulin resistance, an underlying cause of the disease.
In this controlled trial, researchers found that adding Avandia to metformin therapy had a positive effect on several metabolic deficiencies of type 2 diabetes, including insulin resistance and certain lipid parameters. Specifically, Avandia increased high density lipoprotein (HDL or "good") cholesterol, reduced triglycerides and significantly decreased free fatty acid levels. Elevated levels of free fatty acids have been associated with insulin resistance, and with possible damage to the insulin-producing beta cells in the pancreas. In addition, this study reported a low incidence of hypoglycemia (or low blood sugar) in all treatment groups.
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