Journal of Clinical Endocrinology & Metabolism
04/26/2002
By David Loshak
Oestrogen-androgen replacement therapy can improve body composition, lower-body muscle strength, quality of life and sexual functioning in postmenopausal women with no noteworthy side-effects, say researchers.
Menopause is associated with reduced lean body mass and increased fat due to ageing and declining hormone secretion. Researchers at Johns Hopkins University School of Medicine, Baltimore, Maryland, and Solvay Pharmaceuticals Inc., Marietta, Georgia, noted that oestrogens or oestrogen-progestins had been used to alleviate vasomotor symptoms but that oestrogen-androgen therapy, also used for vasomotor symptom relief, had been shown to increase lean body mass while reducing fat mass.
They conducted a 16-week, double-blind, randomised, parallel group clinical trial in 40 postmenopausal women of mean age 57 years. The study examined the effects on body composition of esterified oestrogen 1.25 mg/day plus methyltestosterone 2.5 mg/day versus esterified oestrogen 1.25 mg/day alone.
Compared with oestrogen alone, oestrogen-androgen significantly increased total lean body mass and reduced the percentage fat for all body parts, lean body mass increased by 1.232 kg. (2.72 lb). Of this, 0.181 ± 0.004 kg. (0.40 ± 0.009 lb.) was in the upper body, 0.81 kg. ± 0.057 kg. (1.79 lb. ± 0.13 lb.) was in the trunk and 0.24 ± 0.009 kg. (0.53 ± 0.02 lb.) was in the lower body.
In those who received oestrogen only, the increases were 0.31 ± 0.004 kg.( 0.68 ± 0.009 lb.) in the upper body, 0.021 kg. ± 0.03 kg. (0.05 ± 0.07 lb.) in the trunk and 0.056 kg. ± 0.05 kg. (0.12 ± 0.11 lb.) in the lower body
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