Diabetes, Obesity & Metabolism
04/16/2002
By Mark Greener
Intensive treatment with pre-prandial insulin lispro and nocturnal isophane is associated with equivalent physiological responses to hypoglycaemia as is soluble insulin.
Intensive basal and bolus regimens including insulin lispro produce similar glycaemic control to human-soluble insulin. However, insulin lispro reduces hypoglycaemia rates. Against this background, researchers from the University of Sheffield, and other UK centres, examined whether rapidly acting analogues prevent defective hypoglycaemic counter-regulation among patients taking intensive insulin regimens.
The authors enrolled four women and six men, aged a mean of 33 years, who had type 1 diabetes for an average of 12 years in an open, randomised, crossover study. The patients took lispro or human-soluble insulin before meals and human NPH insulin (isophane) at night for four months.
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