04/11/2002
By Harvey McConnell
Women who take antiepileptic drugs during pregnancy have triple the risk of congenital malformation or developmental delay in their offspring.
As many women must continue to take medication during pregnancy despite the teratogenic risk, the only alternative is development of safer drugs, argues Dr David Lloyd and colleagues at the Department of Neonatal Medicine, Aberdeen Maternity Hospital, Aberdeen, Scotland.
An estimated 6.1 per 1,000 pregnancies are among women with epilepsy, making it the most common major neurological disorder in pregnancy requiring continuous treatment, the clinicians said. Offspring of the mothers taking anti-epileptic drugs (AEDs), such as phenytoin, carbamazepine, and sodium valproate may develop problems.
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