Movement Disorders
03/29/2002
By Robert Short
There is a positive association between smoking and dementia, when seen in the context of Parkinson's Disease.
The surprising conclusion comes from a study of a 180 non-demented patients with Parkinson's disease in New York. The mean age of the patients was 71 years at the study start and they were followed up for a mean of 3.6 years. In that time, 52 of the 180 patients (29 percent) became demented. This did not seem to be related to head injury risk ratio, hypertension or diabetes mellitus, according to Cox models.
However, patients who reported having 'ever smoked' were at increased risk for the development of dementia compared with 'nonsmokers' (risk ratio 2.0; P=0.05). 'Current smoking' was significantly associated with dementia occurring (risk ratio 4.5; P=0.02). 'Past smoking' approached significance (risk ratio 1.9;P=0.07).
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