ATLANTA, GA — March 18, 2002 — Chronic renal disease is a significant independent risk factor for major adverse cardiac events (MACE) after a percutaneous coronary intervention (PCI), investigators said at the 51st Annual Scientific Session of the American College of Cardiology (ACC). In fact, the results indicate that there is a severalfold increase in post- procedural mortality in patients with renal failure.
The data were reported by Dr. Robert Minutello with New York Presbyterian Hospital-Weill Medical College of Cornell University in New York City.
Patients with renal dysfunction often have co-morbidities placing them at greater risk for adverse outcomes following PCI, he noted. It is unclear whether renal dysfunction itself is an independent predictor for adverse events post- PCI.
Interventional cardiologists in the state of New York are required to provide the state with detailed information of every PCI attempted. This database contains information regarding peri-procedural medications, clinical and angiographic risk factors, coronary anatomy, and major in-hospital events.
Dr. Minutello's team used the New York State database to compare baseline clinical and angiographic characteristics between patients with renal dysfunction and those without severe renal impairment at the time of the PCI.
Renal dysfunction was defined as a creatinine of greater than 2.5 mg/dl or requiring dialysis.
Post-procedural MACE defined as death, emergent coronary artery bypasss graft surgery, or Q wave MI were compared between the two groups.
Among approximately 22,000 patients included in the data analysis, 370 (1.7 percent) patients had renal dysfunction, and of those, 45 percent were on dialysis.
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