מתוך medicontext.co.il
NEW YORK (Reuters Health) – The presence of type II diabetes does not prevent the recruitment of collateral vessels or the normal reduction in myocardial ischemia after repeated balloon inflations during coronary angioplasty, Greek researchers report in the January issue of Heart.
In fact, lead author Dr. Zenon S. Kyriakides told Reuters Health that the findings establish that "ischemic preconditioning is intact in [such] diabetic patients."
Dr. Kyriakides and colleagues, at Onassis Cardiac Surgery Centre, Athens, note that collaterals develop in the advanced stages of coronary atherosclerosis. Furthermore, during coronary angioplasty, the severity of myocardial ischemia during balloon inflation decreases as inflations are repeated.
To determine whether type II diabetes might alter collateral circulation, the researchers studied 18 diabetic and 38 nondiabetic angioplasty candidates, all of whom underwent at least 3 balloon inflations.
The ratio of coronary artery to mean arterial pressure increased by 18% from the first to the third inflation in the diabetic patients, but only by 3% in the nondiabetics. This showed, say the investigators, that "collateral circulation is not diminished but enhanced" in diabetics. The response was not altered by type of diabetic treatment.
In another group of 18 diabetic and 39 nondiabetic patients undergoing the same procedure, surface and intracoronary ECGs established that there was no difference in the normal reduction of myocardial ischemia following repeated balloon inflations.
Among possible reasons for the observed improved collateral recruitment in the diabetics, the researchers conclude, may be "more collateral neoangiogenesis" or "secretion of higher concentrations of vasoactive substances."
e-Med Tools
קצר קולע וממוקד
e-Med סמינרים
אי-מד תחקירים
Medscape Tools
Journal Club
מרכזי מידע ושירות
Facebook
מידע למפרסם
מאגר תרופות
מאגר אנשי המקצוע
אינדקס שימושי
חדשות משה"ב
eMed HealthClub
מחקרים קליניים
השאירו תגובה
רוצה להצטרף לדיון?תרגישו חופשי לתרום!