WESTPORT, CT (Reuters Health) – Elevations in intramyocellular lipid content (IMCL) parallel decreases in insulin sensitivity in healthy, nondiabetic volunteers, according to a report in the November 15th issue of Diabetes.
IMCL levels can increase in response to high-fat feeding and decrease after prolonged moderate exercise, the authors explain, but how quickly these changes occur and whether they relate to changes in insulin sensitivity has not been explored in detail.
Dr. Hans U. Hהring and colleagues from Eberhard-Karls University in T?bingen, Germany studied the effect of hyperinsulinemia and elevated circulating fatty acid levels in IMCL formation and insulin sensitivity in 12 healthy male subjects.
Insulin infusion had no effect on IMCL levels, the authors report, but concomitant infusion of insulin and nonesterified fatty acids brought steady increases in IMCL levels.
After a high-fat diet, the report indicates, IMCL content increased and insulin sensitivity decreased.
"The increases in IMCL levels and decreases in insulin sensitivity [during the lipid infusion protocol] paralleled one another and showed a strong negative correlation over time," the researchers note.
"The close correlation of time course and degree of change in both parameters are suggestive of a potential link between IMCL levels and muscle insulin sensitivity," the authors conclude. "The results of the diet protocol suggest that this is a physiologically relevant regulatory mechanism."
Diabetes 2001;50:2579-2584.
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