By Melissa Schorr
SAN FRANCISCO (Reuters Health) – People who routinely take nonsteroidal anti-inflammatory drugs (NSAIDs) other than aspirin may not receive the benefits of a reduced risk of heart attack, according to research presented here Tuesday at the American College of Rheumatology's annual meeting.
"NSAIDs as a group had no clear protective benefit against myocardial infarction," said lead author Dr. Daniel H. Solomon, a rheumatologist and epidemiologist at Harvard Medical School and Brigham and Women's Hospital in Boston, Massachusetts.
For the years 1991 to 1994, Dr. Solomon and colleagues compared the prescription drug use of nearly 5,000 MI patients with more than 20,000 patients matched for age and gender who had not experienced MI.
"With non-users of non-steroidals as the reference group, we find taking any NSAID was not associated with any change in the risk of myocardial infarction," Dr. Solomon told Reuters Health. He reported that naproxen was initially shown to confer a 16% reduction in the risk, but when the data were adjusted for length of drug half-life, that finding was not statistically significant.
"Naproxen appears to be associated with a slightly reduced risk of heart attack, but not at the level of the reduction that aspirin confers," Dr. Solomon concluded. "This has raised the hypothesis that nonselective NSAIDs may confer a small benefit, but confirmation is important."
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