מתוך medicontext.co.il
NEW ORLEANS (Reuters Health) – A history of depression is associated with earlier onset of perimenopause, according to results of a small study presented at the 12th annual meeting of the North American Menopause Society.
Dr. Lee S. Cohen and colleagues, of Harvard Medical School in Boston, followed 34 women aged 36 to 44 for 3 years. Women had follicle-stimulating hormone (FSH) levels assessed at baseline and periodically during followup. Perimenopause was defined as "onset of irregular menstrual cycles and/or initiation of estrogen replacement therapy for vasomotor symptoms," Dr. Cohen said.
"Time to perimenopause was measurably shorter in the women with a history of depression," Dr. Cohen reported. A higher mean FSH level at baseline was associated with a longer time to perimenopause. Dr. Cohen said that depression appears to have a "direct effect" on gonadotrophin levels.
In an interview with Reuters Health, Dr. Cohen said the findings are suggestive of "cross-talk between the neuroendocrine system and the reproductive endocrine system." He said similar associations have been seen in "studies that indicate girls who have early menarche have a higher risk for depression."
Moreover, Dr. Cohen and his colleagues have published studies that suggest estrogen may have some efficacy in treatment of depression. Although "the new data are exciting," Dr. Cohen said, he is not recommending that estrogen monotherapy be considered as a treatment for women with a history of major depressive disorder.
"It may be appropriate for treatment of new-onset depression, but given the reams of information that point to the efficacy of approved antidepressants, it is difficult to make a case for estrogen therapy for depression," he commented.
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