A study published in the July 2002 issue of Diabetes Care provides strong evidence that women with type 2 diabetes are at substantially elevated risk of morbidity and mortality from cardiovascular disease even before their diabetes is diagnosed.
The study by Frank B. Hu and colleagues followed 117,629 female nurses for 20 years. At the time of recruitment in 1976, the women were between 30 and 55 years of age and were free of diagnosed cardiovascular disease, although 1508 women had been diagnosed with type 2 diabetes.
Over the following 20 years, 5,894 women more developed the disorder. During 2.2 million person-years of follow-up, the researchers documented 1,556 new cases of myocardial infarction, 815 cases of fatal coronary heart disease, 1,405 strokes, and 300 fatal strokes. Among women who developed type 2 diabetes during the follow-up period, the age-adjusted relative risks of myocardial infarction were 3.75 (95% CI 3.10-4.53) for the period before the diagnosis and 4.57 (95% CI 3.87-5.39) after diagnosis, compared with women who had remained free of a diabetes diagnosis.
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