Nitric oxide (NO) induces increased expression of matrix metalloproteinase (MMP) mRNA in human melanoma cells, Japanese researchers report. They believe that MMP gene transcription may be associated with tumor progression under inflammatory conditions.
Dr. Hiroyasu Esumi, of the National Cancer Center Research Institute East in Kashiwa, Chiba, and coinvestigators, used the reverse transcription-polymerase chain reaction to investigate expression of MMPs in two melanoma cell lines after exposure to an NO-generating agent. In both cell lines, MMP-1 and MMP-10 mRNA increased, and in one of them MMP-3 and MMP-13 mRNA also increased.
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