Stem cell factor expression rapidly increases early in wound healing but later declines. The expression of the Kit receptor in mast cells is induced slowly in healing wounds.
In chronic wounds and psoriatic lesions, both stem cell factor and Kit are intensely expressed. These findings, say researchers in Helsinki and Kuopio, Finland, suggest that in chronic wounds and psoriasis, stem cell factor and Kit receptor might interact leading to persistent mast cell activation and growth.
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