Aug. 12, 2002 As an adjunct to anti-inflammatory medications, a moisturizer containing ceramide dramatically improved atopic dermatitis symptoms and reversed underlying damage, according to a report in the August issue of the Journal of the American Academy of Dermatology.
“Topical glucocorticoids and other immunosuppressive agents are mainstays of therapy, but the risk of toxicity from these agents is not insignificant, particularly in children,” write Sarah L. Chamlin, MD, and colleagues from the University of California, San Francisco. “Because stratum corneum permeability barrier function is also abnormal in atopic dermatitis, it has been hypothesized that the barrier abnormality could drive disease activity. Yet commonly used emollients and moisturizers do not correct the stratum corneum ceramide deficiency, the putative cause of the barrier abnormality.”
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