LOS ANGELES, CA — May 7, 2002 —
A double-blind study comparing ethinyl estradiol (EE)/desogestrel to EE/levonorgestrel found that both drugs were effective for reducing acne lesions.
These findings, reported here yesterday at the 50th Annual Meeting of the American College of Obstetricians and Gynecologists, contradict marketing claims that promote some oral contraceptives as being less androgenic and thus more effective for the treatment of acne vulgaris.
Daniel M. Breitkopf, MD, assistant professor, University of Texas Medical Branch at Galveston, Texas, United States, and colleagues enrolled 34 women in the study. Nine women in the EE/levonorgestrel group and seven women in the EE/desogestrel group completed the nine-month treatment course.
There was no difference between mean age, body mass index, baseline SHBG, or baseline free and total testosterone, Dr. Breitkopf said. Women with congenital adrenal hyperplasia, androgen secreting tumors, or Cushing’s syndrome were excluded from the study. Women taking hormones during the two months preceding enrollment were also excluded.
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