Resistant propionibacteria, widely distributed on acne-prone skin and in the nares, may be difficult to eradicate using existing treatments, say specialists in Leeds, England.
Although cutaneous propionibacteria were implicated in acne pathogenesis, the exact role in causing inflammation was unclear. Also, there were few formal data on prevalence and distribution. Antibiotics and other agents which reduced the numbers of propionibacteria on skin were therapeutic but resistance in the target organism often developed.
The specialists monitored the prevalence of skin colonisation by antibiotic-resistant propionibacteria in 4,274 acne patients at a dermatology out-patient clinic over 10 years from 1991. They also examined the distribution of resistant strains on acne-prone skin and in the nares.
The specialists obtained propionibacterial samples from the skin surface of the worst affected site, usually the face, with a moistened swab. The swab was used to inoculate agar plates with and without selective antibiotics. After anaerobic incubation at 37°C for seven days, the amount of growth in the presence of each antibiotic was scored.
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