British Journal of Dermatology 05/16/2002 By David Ball
Sunscreen use does not appear to cause cutaneous malignant melanoma, according to analysis of epidemiologic and case-control studies.
Findings from the analysis were contradictory but did not suggest a causative association, say Sylvie Bastuji-Garin at the Henri-Mondor Hospital, Créteil, France and a colleague at the University Hospital Heidelberg, Germany.
For example, while two case-control studies showed sunscreen use had a protective effect, three found a significant risk associated with the most serious form of skin cancer. In addition to the conflicting results, the researchers note that relative risks were low, and studies fail to clarify whether sunscreen exposure precedes disease and fail to demonstrate a dose-effect relationship.
The researchers classified studies into four categories: those found to be inconclusive due to major bias in control population and/or the lack of multivariate analysis; those that showed no association after controlling for confounders; those that showed a negative, or protective, association of sunscreen; and those that showed a positive association.
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