By Veronica Rose
Cardiac function following myocardial infarction may be predicted by plasma brain natriuretic peptide levels, according to Japanese researchers.
That association would appear to underscore the importance of early recanalization in recovery, say clinicians at Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya-City, Japan. Brain natriuretic peptide (BNP) levels have in the past undergone frequent measurements in patients with myocardial infarction.
However, it has been unclear whether recanalization modulates BNP levels, and whether those levels can predict ventricular function.
To clarify these issues, researchers measured BNP levels in 80 consecutive patients with acute myocardial infarct (AMI) at admission and at four hours, 24 hours, 48 hours and a month following admission.
In 35 patients, the infarct-related artery was patent within six hours of the onset of MI (“six-hour patency group”), while in 27 patients the artery was still occluded after six hours (“six-hour occlusion group”). Eighteen patients, in whom it was unclear whether recanalization had occurred, were excluded from the study.
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