GENEVA, SWITZERLAND — June 3, 2002 —
The early risk of having a stroke after a transient ischemic attack (TIA) is higher than suggested by previous research, investigators reported here Friday at the European Stroke Conference. Previous studies suggested an early risk of stroke after a first-ever TIA of 2 percent at seven days and 4 percent at four weeks.
These figures, however, may underestimate the true risk because of delays before stroke subjects entered the studies and the exclusion of strokes during this time, according to J.K. Lovett, MD, lead investigator for the Stroke Prevention Research Unit of the Department of Clinical Neurology, Radcliffe Infirmary, Oxford, United Kingdom.
“The early risk of stroke after a TIA is therefore unknown, and guidelines vary on how urgently patients should be investigated,” the researchers wrote in describing their reason for undertaking their study, which used data from the Oxfordshire Community Stroke Project to estimate the early risk of stroke after a TIA. They made two analyses of data from the Oxfordshire Project.
In analysis 1, they evaluated the records of 179 patients whose notification event was a TIA and whose median length of notification was six days. In analysis 2, they evaluated the records of 209 patients who had definitely experienced a first-ever TIA within the period of the study.
They found that the seven-day stroke risk after a first-ever TIA was 1.7 percent (95 percent confidence interval 0-3.6 percent) in analysis 1 and 8.6 percent (4.8-12.4 percent) in analysis 2. The 30-day risks were 3.4 percent (0.7-6.0 percent) and 12.0 percent (7.6-16.4
percent) respectively
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