05/27/2002 By Elda Hauschildt
Use of naproxen, a non-steroidal anti-inflammatory drug (NSAID), has been associated with reduced risk of heart attack.
Naproxen was associated with an apparent 16 to 20 percent reduction in AMI risk in a case-control study of AMI using information from a large United States health-care database. Researchers from Brigham and Women’s Hospital, Harvard Medical School in Boston, Massachusetts, point out that aspirin has long been shown to protect patients against acute myocardial infarction (AMI).
They found use of most other NSAIDs does not. “Although NSAIDs have anti-inflammatory and anti-platelet effects similar to those of aspirin, we do not find that these drugs confer a protective effect against AMI,” say investigators led by Dr. Daniel H. Solomon. However, “use of one specific NSAID, naproxen, appeared to be associated with a reduced rate of AMI, an effect recently suggested by a large, randomised controlled trial as well.
” The investigators suggest there are substantial clinical implications if these findings are confirmed in other populations. It means patients who regularly use most NSAIDs also require the cardio-protective effect of aspirin.
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