05/23/2002 By James Adams
Losartan normalizes the response of the left main coronary artery to the cold pressor test in patients with essential hypertension independently of blood pressure.
Losartan is an angiotensin II type 1 receptor antagonist which mediates the impairment of endothelial function caused by angiotensin II.
Investigators from Tongji Medical College at Huazhong University of Science and Technology in Wuhan, China, hypothesized that losartan would restore normal dilation of the left main coronary artery in response to the cold pressor test. Twenty-four patients with mild to moderate essential hypertension and 24 matched, healthy controls were studied. Changes in left main coronary artery diameter in response to the cold pressor test and to nitroglycerin administration were measured by echocardiography after a washout period and after 12 weeks of losartan treatment.
Percentage change in the left main coronary artery diameter in response to the cold pressor test before losartan treatment was significantly lower in patients with essential hypertension (-4.3 ± 8.7 percent) compared with controls (10.5 ± 3.9 percent). Treatment with losartan increased the percentage change in the hypertensive patients to 13.7 ± 8.0 percent. There was no significant difference between the 14 hypertensives who had satisfactory blood pressure control and the 10 patients who did not.
e-Med Tools
קצר קולע וממוקד
e-Med סמינרים
אי-מד תחקירים
Medscape Tools
Journal Club
מרכזי מידע ושירות
Facebook
מידע למפרסם
מאגר תרופות
מאגר אנשי המקצוע
אינדקס שימושי
חדשות משה"ב
eMed HealthClub
מחקרים קליניים
השאירו תגובה
רוצה להצטרף לדיון?תרגישו חופשי לתרום!