WESTPORT, CT (Reuters Health) – Over time, lower initial measures of lung function (FEV1) are associated with a greater degree of bronchial hyperreactivity (BHR) in asthmatic children, according to Turkish researchers.
Dr. Nerin N. Bahceciler and colleagues at Marmara University Hospital in Istanbul investigated factors such as the severity of allergy and measures of lung function as predictors of the severity of BHR in childhood asthma.
Accordingly, in 98 asthmatic children, the researchers examined risk factors at referral which bore a relationship with BHR at a mean of 3 years' followup. The findings were published in the October 1st issue of the American Journal of Respiratory and Critical Care Medicine.
No relationship was seen with markers such as serum IgE levels or with skin-prick test results for a panel of 24 allergen extracts. Furthermore, at 3 years' followup, there were no significant changes from baseline in these results.
However, BHR–as measured by the concentration of methacholine required to cause a 20% drop in FEV1 (PC20)–was associated with lung function.
Thus, a lower level of FEV1 % at referral, the investigators conclude, "was found to be an important predictor of more severe BHR at the end of the followup."
Am J Respir Crit Care Med 2001;164:1150-1153
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