NEW YORK (Reuters Health) Feb 28 – HIV protease inhibitors (PIs) have antiangiogenic and antitumor activity at concentrations achieved in the plasma of individuals treated with these drugs, Italian investigators report.
Reporting in the March issue of Nature Medicine, Dr. Barbara Ensoli, of the Istituto Superiore di Sanita in Rome, and colleagues treated nude mice with indinavir, saquinavir, or saline for 2 days. After injecting them with different strains of Kaposi's sarcoma (KS) cells, PI treatment was continued for 5 days.
KS-like lesions were reduced by 25% to 43% in treated mice compared with untreated animals. Lesions in PI-treated mice were less florid and exhibited less neovascularization and decreased spindle-cell infiltration. Even when PIs were administered at the same time as KS-cell inoculation, lesions showed significant regression.
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