05/23/2002 By Anne MacLennan
Carotenoids may well protect women against breast cancer, a study from Johns Hopkins University, Baltimore, Maryland and Our Lady of Mercy Medical Center, Bronx, New
York, United States, has concluded.
This suggestion adds weight to those of earlier studies that the antioxidant properties of carotenoids and vitamin E (g-tocopherol) and the role of vitamin A in cellular differentiation may be linked with a reduced risk of subsequent breast cancer. Reiko Sato and colleagues compared 295 women who gave blood for a serum bank in 1974 or 1989 with 295 controls matched on a range of factors.
The investigators were looking for the association between serum and plasma concentrations of retinol, retinyl palmitate, a-carotene, ß-carotene, ß-cryptoxanthin, lutein, lycopene, total-carotenoids, a-tocopherol and g-tocopherol with subsequent development of breast cancer. Median concentrations of ß-carotene, lycopene and total carotene were found to be significantly lower in the cases versus controls in the 1974 cohort and for lutein in the 1989
cohort.
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