Orthotopic renal transplant worth considering for patients with iliac atherosclerosis

WESTPORT, CT (Reuters Health) – In patients with severely atherosclerotic iliac vessels or failed bilateral iliac fossa renal transplant, orthotopic renal transplantation can result in excellent patient and graft survival, researchers report in the November issue of The Journal of Urology.

Dr. Darius A. Paduch and colleagues from Oregon Health Sciences University in Portland reviewed the records of five such patients who underwent left orthotopic renal transplantation between August 1993 and August 2000. Two of the patients received kidneys from living related donors and three received cadaveric organs.

In four patients, the procedure was successful. Due to a pulseless splenic artery and renal artery thrombosis after native renal endarterectomy, the other patient was converted to iliac fossa renal transplant, the researchers report. Revascularization was accomplished using the splenic artery in two patients, the native renal artery in two and the left renal vein in all four successful patients.

Before the procedure, mean serum creatinine was 7.9 mg/dL, and it was 1.3 mg/dL at 1 month after transplantation, Dr. Paduch's team notes. At last followup, which at the time the report was written was 6 months in 4 cases and 5 years in one case, the survival rates for patients and grafts were both 100%.

In the paper, the investigators describe the technical aspects of the procedure in more detail and advocate the use of intraoperative heparin for this patient population.

J Urology 2001;166:1647-1650.

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