New data reported today at the Society of Critical Care Medicine’s 32nd Critical Care Congress suggest that intrapleural streptokinase treatment can help manage complicated parapneumonic effusions in pediatric patients.
Dr. Jieh-Neng Weng and colleagues at the National Cheng Kung University Hospital in Tainan, Taiwan, compared results in 20 consecutive children who received intrapleural streptokinase for complicated parapneumonic effusions and 22 consecutive control patients who had received chest tube drainage without streptokinase.
Coagulation profiles were checked in all patients in the streptokinase group before the fibrinolytic was administered. The drainage test tube was clamped and streptokinase 12,000 units /kg in 50 mL of 0.9% saline solution was instilled into the chest tube. Patients were rotated in several positions to facilitate pleural distribution, and the tube remained clamped for two hours. After unclamping, tubes were placed back on 5-20 cm H20 suction and drainage was recorded.
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