Supplementing critically ill surgical patients with antioxidant vitamins C and E reduced risk of organ failure, ventilator support, and length of intensive care unit (ICU) stay, according to the results of a randomized, prospective trial published in the December issue of the Annals of Surgery.
“Oxidative stress has been associated with the development of the acute respiratory distress syndrome (ARDS) and organ failure through direct tissue injury and activation of genes integral to the inflammatory response,” write Avery B. Nathens, MD, from the University of Washington, and colleagues. “In addition, depletion of endogenous antioxidants has been associated with an increased risk of nosocomial infections.”
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