Current methods of assessing platelet activation does not appear to predict outcome in heart failure patients. Paul Gurbel, MD, from the Sinai Center for Thrombosis Research, Baltimore, Maryland, and colleagues, studied 96 consecutive outpatients with ambulatory heart failure (NYHA Class II – IV) presenting at the Duke Heart Failure Clinic, and 14 healthy control subjects. The median age of the patients was 65 years.
In patients with mild to moderate heart failure, an ischaemic aetiologic condition was present in 61 percent of patients. Over a median of 305 days, there were 39 clinical events (seven deaths, three cardiac transplants, and 29 first hospitalisations for other reasons).
Platelet activity was measured by whole blood aggregation with 5 µmol adenosine diphosphate. Platelet activity measured in this way was higher in patients with heart failure than in the healthy controls.
However, platelet function did not differ for any of a wide range of markers between the ischaemic and non-ischaemic groups and was not affected by aspirin therapy. There was also no relation of NYHA class or the occurrence of events to platelet activity.
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