מתוך medicontext.co.il
NEW YORK (Reuters Health) – Asthmatic patients have a faster increase in exhaled air temperature during a single breath compared with normal subjects, which correlates with nitric oxide (NO) concentrations, UK researchers report.
Dr. Peter J. Barnes, from the National Heart and Lung Institute, London, and colleagues measured exhaled air temperature in 18 patients with asthma and in 16 normal subjects. The researchers also compared NO concentrations, as a marker of inflammation, with exhaled air temperature.
In both asthmatics and controls the end-expiratory plateau temperature was similar (mean 35.75 versus 34.45 degrees C, (p > 0.05). However the rate of increase in exhaled air temperature was higher in asthmatics (mean 8.17 degrees C per second) compared with controls (mean 4.12 degrees C per second, p < 0.01), the researchers found. The rate of change of exhaled air temperature also positively correlated with NO (p = 0.034) in asthmatics.
After the subjects were given albuterol, the rate of exhaled air temperature rise in controls increased from a mean of 4.28 to 7.60 degrees C per second (p < 0.01), but did not increase in asthmatics, Dr. Barnes' team found. This may be an indicator of bronchial blood flow, according to their report in the January 15th issue of the American Journal of Respiratory and Critical Care Medicine.
Dr. Barnes and colleagues conclude that "measurement of exhaled breath temperature may be another means of detecting and monitoring cytokine- and oxidant-mediated inflammation and of assessing anti-inflammatory treatments."
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