מתוך medicontext.co.il
WESTPORT, CT (Reuters Health) – In renal transplant recipients, hematocrit and hemoglobin values are directly related to carotid intima-media thickness (IMT), a marker of atherosclerotic disease, according to a recent report.
Dr. Szymon Brzףsko and colleagues from the University School of Medicine in Bialystok, Poland used ultrasound to measure the carotid IMT of 33 clinically stable renal transplant recipients and of 19 healthy subjects. Clinical parameters such as mean arterial pressure and pulse pressure were determined and hemoglobin, hematocrit, fibrinogen, and homocysteine concentrations were measured.
Mean hemoglobin and hematocrit values were lower in the transplant group than in the control group, the authors note. In contrast, mean carotid IMT, fibrinogen, homocysteine, mean arterial pressure, and pulse pressure were significantly lower in the control group.
In the transplant group, IMT was directly related to patient age, hemoglobin, hematocrit, pulse pressure, fibrinogen, and time on dialysis prior to transplantation. Further analysis revealed that hemoglobin, hematocrit, and fibrinogen were independent predictors of IMT, the investigators state in the October issue of Clinical Transplantation.
The current findings are the first to show that hemoglobin and hematocrit values are directly related to carotid IMT, the researchers note. "The results may implicate the role of these rheological factors in progression and acceleration of arterial remodeling in renal transplant recipients."
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