Supplementation with folic acid significantly enhances endothelial function and reduces blood pressure in young, chronic smokers.
Smoking cigarettes is known to increase plasma homocysteine, explain investigators, which in turn induces endothelial dysfunction and arterial stiffening, contributing to the vascular abnormalities observed in smokers.
The investigators, from Guy’s, King’s and St Thomas’ School of Medicine at King’s College London, England, studied 24 healthy cigarette smokers to determine if folic acid supplementation, which reduces homocysteine levels, could improve endothelial function and arterial stiffness. Smokers were randomly assigned to receive either 5 milligrams of folic acid or placebo every day.
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