Treatment with the angiotensin-converting enzyme inhibitor (ACE) ramipril resulted in significantly lower mortality in hospital compared with no treatment with other generic ACE inhibitors among a large cohort of patients with ST-elevation acute myocardial infarction.
The prospective multi-centre Maximal Individual Therapy of Acute Myocardial Infarction PLUS registry (MITRA PLUS) study assessed the impact of ramipril treatment compared with other angiotensin-converting enzyme inhibitors on clinical outcome in unselected patients. The study was directed by Harm Wienbergen, MD, Herzzentrum Ludwigshafen, and collaborators at Klinikum im Friedrichshain, Berlin, and the Robert-Koch-Krankenhaus, Gehrden, Germany.
Among 14,608 consecutive patients with ST-elevation acute myocardial infarction, 4.7 percent received acute therapy with ramipril, 39.0 percent received other ACE inhibitor therapy, and 56.3 percent received no ACE inhibitor therapy.
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