Preliminary findings from two recent studies indicate that the process of assisted reproduction can cause the genetic disruption associated with the disorder Beckwith-Wiedemann syndrome (BWS). New research from the U.K., published in the January issue of the Journal of Medical Genetics, found that children with the syndrome were four times more likely than the general population to have been conceived by assisted reproduction.
A similar study of BWS patients conducted in the U.S. found that patients were six times as likely to have been conceived through in vitro fertilization (IVF). Although the numbers are small with six identified BWS cases out of roughly 40,000 assisted reproduction births during the time of the U.K. study they offer some of the strongest evidence yet that assisted reproduction techniques like IVF and intracytoplasmic sperm injection (ICSI) carry a risk of genetic imprinting disorders.
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