Patients hospitalized for a manic episode due to type I bipolar disorder respond rapidly to monotherapy with the antipsychotic agent risperidone, psychiatrists reported today. The drug also relieves concurrent symptoms of depression.
Dr. Robert M. A. Hirschfeld, of the University of Texas Medical Branch in Galveston, and colleagues enrolled 259 hospitalized patients from 20 sites in the US in their placebo-controlled trial. Treatment for the 134 subjects assigned to risperidone was initiated at 3 mg/day, adjusted to doses of 1 to 6 mg/day as needed.
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