Growth hormone (GH) alone or in combination with sex steroids should not be used outside of controlled trials, according to the results of a study reported in the Nov. 13 issue of The Journal of the American Medical Association.
These drugs increase lean body mass and decrease fat mass, and increase cardiovascular endurance a little in older men, but there are significant adverse effects. “Although this study suggests that GH or related substances, particularly given in combination with testosterone in older men, may one day be a promising therapeutic agent in the treatment of certain age-related conditions, it is not ready for prime time,” lead author Marc R. Blackman, MD, from the National Institutes of Health in Bethesda, Maryland, says in a news release. “There is much that we still don’t know about its efficacy and, more importantly, there are too many known and potential adverse consequences associated with it. It is a fascinating and promising area of research, but at this time we can’t recommend it for use outside of a carefully controlled and monitored clinical trial.”
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