Giving atorvastatin every other day was as effective in lowering low-density lipoprotein cholesterol (LDL-C) levels as giving it daily, according to a pilot study reported in the October issue of the American Heart Journal. The mean dose was higher but the average daily dose was lower, resulting in cost savings.
“The average monthly cost for each 1% reduction in LDL-C resulted in annualized cost savings of $269 per patient for the alternate-day group,” write Mazen S. Matalka, PharmD, from the Veterans Administration Central California Health Care System in Fresno, and colleagues.
In the Alternate Day Versus Daily Dosing of Atorvastatin Study (ADDAS), a double-blind, placebo-controlled pilot study, 35 eligible patients who met National Cholesterol Education Program (NCEP) Adult Treatment Panel II (ATP II) guidelines for drug therapy were randomized to treatment with 10 mg of atorvastatin as an initial dose daily or every other day. At six and 12 weeks, the dose was doubled in patients who had not met the LDL-C goal.
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