Laurie Barclay, MD Oct. 3, 2002
Complications from long-standing diabetes may respond to new treatment strategies reported in the October issue of Diabetes Care.
Because diabetic neuropathy can be a painful condition that may be associated with nitric oxide (NO), investigators tested a spray containing isosorbide dinitrate (ISDN), a common NO donor used for heart patients, and found that it reduced overall neuropathic pain and burning with no effect on other symptoms. A letter in the same issue reported on two patients with diabetic gastropathy in whom sildenafil improved gastric emptying and clinical symptoms, suggesting a possible mechanism and new therapy for diabetic gastropathy.
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