Aspirin appears to significantly reduce the incidence of preeclampsia, gestational hypertension, intrauterine growth retardation (IUGR) and preterm delivery, but the effect seems to be time dependant.
This research was presented Thursday at the American Heart Association’s 56th Annual High Blood Pressure Research Conference by Ramon C. Hermida, PhD of the University of Vigo, Vigo, Spain.
He said that administration of aspirin at bedtime is likely to be more effective because “the body’s metabolism slows with sleep so the aspirin is present longer. Based on the results of this study, we would recommend that women who are at risk for gestational hypertension or preeclampsia be offered a trial of low dose aspirin beginning no later than the 16th week of pregnancy.
This protective effect is not apparent when aspirin is initiated later in pregnancy.” Dr. Hermida and co-author Diane E. Ayala, MD, PhD enrolled 341 women, including 181 primipara. The women, at 12 to 16 weeks’ gestation, were randomly assigned to one of six treatment groups: aspirin 100 mg on awakening, eight hours after awakening, or at bedtime, or to time matched placebo groups.
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