Amphotericin B plus azole therapy without surgery may be effective treatment for some patients with Coccidioidomycosis osteomyelitis
. Coccidioidomycosis osteomyelitis is a rare and difficult to treat disease, with a lifelong risk of recurrence. LT Keith G. Holley, MC, and colleagues at the Naval Medical Center in San Diego, California, United States, retrospectively reviewed the charts and conducted a telephone follow-up of 13 patients who had been treated for coccidioidomycosis involving bones or joints, at the centre from 1993 to 1999.
Six patients underwent surgical debridement and systemic medical therapy and seven patients received medical treatment only, the researchers reported. All patients improved symptomatically with decreasing complement fixation titers at last follow-up.
Five of the six patients treated with combined therapy are currently quiescent. Of those treated medically, four patients are quiescent and three were lost to follow-up.
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