Preliminary indications are citalopram (Cipramil) is effective in women with severe premenstrual syndrome who have not responded to previous treatment with selective serotonin reuptake inhibitors.
Citalopram, the most selective of the selective serotonin reuptake inhibitors (SSRIs), provided significant improvement in clinical symptoms among a small group of these patients in an open-label study in the United States.
An earlier placebo-controlled study of citalopram showed half-cycle dosing (luteal phase) was effective for DSM-IV-defined premenstrual dysphoric disorder (PMDD), a severe form a premenstrual syndrome (PMS).
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